Pubmedで"tobacco allergy"を検索すると17件。うち16件は1983年以前の論文でなかには[Tobacco allergy--does it exist?]なんていうタイトルの論文もあり不安になりますが、
Tobacco allergy: demonstration of cross-reactivity with other members of Solanaceae family and mugwort pollen.
ttp://www.ncbi.nlm.nih.gov/pubmed/10071524
資料を置いときます。
英語版Wikipedia、「Gold standard (test)」より。
ttp://en.wikipedia.org/wiki/Gold_standard_(test)
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A hypothetical ideal "gold standard" test has a sensitivity of 100% with respect to the presence of the disease (it identifies all individuals with a well defined disease process; it does not have any false-negative results) and a specificity of 100% (it does not falsely identify someone with a condition that does not have the condition; it does not have any false-positive results). In practice, there are sometimes no true "gold standard" tests. Sometimes they are called "perfect" and "alloyed" gold standard.
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『Scientific Foundations and Principles of Practice in Musculoskeletal Rehabilitation』より。
ttp://books.google.co.jp/books?id=59K2W0axcVYC&pg=PA560#v=onepage&q&f=fals （google books）
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The perfect diagnostic test is the gold standard with which all other tests are then compared. Gold standards, by definition, have a sensitivity of 100% and a specificity of 100%.
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ttp://cran.cnr.berkeley.edu/web/packages/HSROC/vignettes/Tutorial.pdf
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We start with the simplest mode, where the reference test is assumed to be a gold standard
(i.e. sensitivity and specificity of the reference test both equal to 100%).
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ttp://www.siue.edu/~sumbaug/RetinalProjectPapers/A%20comparison%20of%20computer%20based%20classification%20methods%20applied%20to%20the%20detection%20of%20microaneurysms%20in%20ophthalmic%20fluorescein%20angiograms.pdf
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An ideal classifier would give 100% sensitivity and 100% specificity, when tested against the
gold standard.
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ttp://calder.med.miami.edu/pages/EBMGlossary.pdf
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For diagnosis, it refers to a reference standard for the evaluation of a diagnostic test. For the purposes of a study, the "gold standard" test is assumed to have 100% sensitivity and specificity. This may well constitute an exaggerated estimate of the reference test.
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ttp://kaken.nii.ac.jp/d/p/14570481
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Unfortunately, however, there is so far no "gold standard" assay (i.e., with 100% sensitivity and 100% specificity) for the detection of AMA in PBC.
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ttp://mice.tropmedres.ac/model103_104.aspx?model_code=MODEL104&showtab=0
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This assumes that the gold standard is perfect (100% sensitive and specific), but this is not always the case.
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ttp://www.chemistrydaily.com/chemistry/Gold_standard_(test)
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An ideal gold standard test has a sensitivity of 100% (it identifies all individuals with a disease process, and it does not have any false-negative results) and a specificity of 100% (it does not falsely identify someone with a condition that does not have the condition; it does not have any false-positive results). There are no ideal gold standard tests.
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ttp://ebem.org/definitions.html#Gold standard
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For the purposes of a study, the "gold standard" test is assumed to have 100% sensitivity and specificity.
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>Despite extensive clinical evidence to support the veracity of this clinical state, many members of the medical community are reluctant to accept this condition as a pathophysiologic disorder.
ttp://www.ncbi.nlm.nih.gov/pubmed/23642291
って書いてあるんですけどね。"many members of the medical community"って、要するに、"the American Academy of Allergy and Immunology, the American Medical Association, the California Medical Association, the American College of Physicians, and the International Society of Regulatory Toxicology and Pharmacology"とかのことでしょう。ちなみにこの総説では私の判断する限りでは"extensive clinical evidence "は述べられていません。"many members of the medical community"の多くのメンバーも私と同じ判断をしたのでしょう。Uptodateの記載も"many members of the medical community"の意見が反映されます。
The following hypothesis can be put forward: The illness mechanism behind MCS involves both physiological and psychological impacts on certain brain centres in particularly predisposed persons.
