最後
“It is very difficult to reconcile the data with simple contamination or careless mislabelling,” says stem-cell scientist George Daley at Harvard Medical School. Requests for comments from corresponding authors of the original papers went unanswered.
The review paper hopes to find a positive lesson in the STAP saga. In the article, Daley, Jaenisch and others detail rigorous ‘forensic’ analysis that they say should be conducted on any purported new types of pluripotent stem cell. This should be done before publication, the article concludes. Daley says that the review is topical because, besides the failed STAP papers, “numerous groups are reporting ever more nuanced states of pluripotency”; the overview focuses on genomic analyses, enabled by advances in sequencing technology, that will help evaluate such cell types.
Daley says that this brings the STAP episode to a close — but with a note to scientists who are looking for ways to reprogram cells to an embryonic-like state: “We will all be a tad more cautious in evaluating such claims.”
Nature doi:10.1038/nature.2015.18412
