>>54
And, we found out diffraction patterns proper to HAp through X-ray crystallographic analysis.
Accordingly, we found out the possibility to compose a new hybrid material made of HAp by alternate immersion method.
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>>55
5.2.4-3 Estimations of bone-regeneration and the quantity of generated bones on implantation-tests in animals
Because HAp produced by this method ( alternate immersion method ) are low in crystality, it’s supposed that though this ingredient induces bone-generation, on the other hand, it can be resolved and absorbed into the living tissue.
Then, an implantation test in a macaca fascicularis was executed to make sure of usefulness, safety for bone-generation under cooperation between medicine and engineering.
>>56
HAp-gels had been homogenized so as to be like a paste for improving operability, such gels had been implanted into a macaca fascicularis with extracted teeth and the state after 90 days from the implantation was observed.
So that, it was made clear that bleeding is stopped within one-minute at the implanted part in comparison with parts without such treatments and the treatment promotes regeneration of alveolar bone.
一
>>57
It’s indispensable in dental treatment to stop the bleeding after pulling out a tooth.
Accordingly, it’s significant that this HAp has not only high absorbability but also good effects originated in components to stop the bleeding.
And, it’s known that it’s possible to regenerate osseous tissues with bone-fillings on-around which formations of HAp are further promoted by electro-chemical methods.
>>58
By the way, taking materials suitable to hard tissues into consideration, resolvability and absorbability are demanded even in some cases which have lower dynamical strength than a living bone.
Here, HAp-gels were implanted into a lacked thigh bone of a rabbit, and we qualitatively estimated bone-regenerative processes in this case.
※ Then, the lack of 5 mm in diameter, of 10 mm in depth.
>>59
Respective states over regenerative processes after the implantation were successively checked with micro-CT .
After two weeks from the implantation, bone-regeneration started around the implanted part.
Furthermore, after 4 weeks from the implantation, regeneration of osseous tissues is actively developed around the implanted part.
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>>60
These results shows that regeneration around the part into which HAp-gels were implanted was significantly more active than those around the part into which agarose gels were implanted.
※ In a word, a part into which HAp-gels were implanted was more active than a part into which agarose gels were implanted in regeneration.
>>61
And, as most of materials for bone-filling until now were radio-opaque, it has been difficult to catch those opaque parts through X-rays.
But, as this HAp-gel has radio-lucency, it’s possible to easily and successively catch transitions of newly developing bones around the part filled with this material by X-rays.
>>62
Furthermore, HAp was implanted into a lacked part of a bone of a rat, we quantitatively estimated variations of the quantity of bone after the implantation.
Then, the quantity of regenerated bone was calculated out as follows with a bone density measuring device.
・ Plural virtual squares and cuboids covering each lack were assumed.
・ And, the quantity of bone was derived from weights of bones contained in those respective ‘sections’ or ‘units’ .
>>63
So that, the bone-density at a part filled with HAp-gel remarkably increased in comparison with parts filled with other materials.
Accordingly, HAp-gel is effective in not only filling of lacked part but also bone-regeneration.
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>>64
5.2.4-4 Applications of HAp-gel to clinical fields
It was made clear through animal tests that HAp-gel was useful as a filling to induce bone-regeneration.
Clinical studies are being executed under the cooperation between medicine and engineering to practically use this material in the dental field.
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>>65
At present ( about 2013 ), to make sure of the safety of HAp-gel based on ISO 10993 , clinical researches for that are being executed by Prof. Masashi.Tabata ( the dental surgery of Miyakonojyou-hospital of Miyazaki prefecture ) and an Assistant Prof. Souichi. Iwai ( the dental department of Osaka university ).
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>>66
We show some of those outlines here.
Following clinical observations were executed under the cooperation between the dental department of Osaka-univ and engineering.
A patient had a lack on one’s own bone after the extraction of cysts on the lower jaw.
Then, HAp-gels were implanted into the lacked part, we checked bone-generation before and after the surgery through X-ray photography.
>>67
For now, clinically harmful problems ( infection, prolonged inflammation, prolongation of time required to heal wounds, etc ) have never been found out.
As shown in pictures, we find out that bone-regeneration remarkably develops after about 12 months from the implantation.
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>>68
Next, we attempted to implant this material into a cleft jaw of a patient suffering from cleft lip and palate in another clinical case.
When a transplant operation is performed on the cleft part of a cleft lip and palate patient,
as it’s possible to sufficiently perform an operation within the mouth, osseous tissues are generally taken out of maxilla or mandible bone due to lower invasiveness to minimize the stress on the patient.
In the case, the main problem is whether the possible quantity to take is small or not.
>>69
Then, we mixed this filling ( HAp-gel ) with PCBM ( Particulate Cancellous Bones & Marrows ) taken out of a chin bone to increase the grafted quantity.
And, the implanted part was observed after six months from the transplantation, we found out that osseous tissues were actively generated around the cleft part.
к
>>70
Following possibilities have been made clear owing to this result.
・ Bone-transplantation on only a small quantity of chin bone
・ Remarkable reduction of invasiveness on a patient with small quantities of bones such as children, in hospitalization period
>>71
Furthermore, in an other case, HAp-gel was applied to a patient suffering from a serious periodontosis ( this case was presented by the dental surgery of Miyakonojyou hospital in Miyazaki prefecture ).
一
>>72
Front teeth on the left lower jaw had been lost to sharpened root parts due to serious periodontosis.
But, we found out that osseous tissues were regenerated around roots of teeth by filling those lost parts with HAp-gels.
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>>73
It was made sure through animal experiments that the hybrid material of agarose gel with HAp as a bio-high molecular material can induce bone-regeneration.
Furthermore, it also was clinically made clear that this material can be effective in healing various diseases such as lacked ( broken ) bone, cleft jaw, periodontosis.
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We also heard that the fellows habitually presenting undesirable advertisements including vulgar ones and fraudulent ones on the net would fight against the world as their enemies from now.
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Indeed, we also heard that the chaps habitually presenting e×tremely erotic advertisements and vulgar ones on the net would fight against the world as their enemies from now.
91:Ground Stone Redux:2020/08/22(土) 17:03:19 ID:1mHKElfQ0
Indeed, we also heard that the people habitually presenting undesirable advertisements such as e×tremely erotic contents and unreliable ones dealing with defective products and fakes on the net would be conveyed to purgatories due to the judgment by the king of Enma (閻魔).
We also heard that the people habitually presenting undesirable contents such as e×tremely erotic & vulgar contents on the net would fight against the world as their enemies, and they would be transferred to ‘purgatories’ .
115:介良事件、甲府事件は wiki にあるのに 仁頃事件がない怪:2021/03/08(月) 14:47:24 ID:NPfbnEgQ0
We heard that the people habitually making violent & annoying noises for intentionally bringing uneasy feelings & harassments to us would fight against the world from now.
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Xmas ;
It’s supposed that respective bands and a gap between bands are embedded in a 2D plane, the embedded gap-zone is ‘twisted’ .
Besides, edges of the ‘twisted gap’ could be viewed for intersecting (≒ crossing) edges.