そうなんだ。でも俺ももう分かったんだ。これは生体内にあってセレクト
してきた細胞かどうか、もはや怪しくなったという次のステップを
予告している to be continued テロップなんだろうよ。
つまり、この細胞は＜Stimulus-triggered fate conversion of somatic cells
into pluripotency＞の結果できたものかもしれないという、現在行なっている
実験を暗示しているんだ。本文があればどんな書かれ方しているのか分かるん
だろうけどね。
Introduction
Low pH triggers fate conversion in somatic cells
Low-pH-induced Oct4+ cells have pluripotency
STAP cells compared to ES cells
STAP cells from other tissue sources
Chimaera formation and germline transmission in mice
Expandable pluripotent cell lines from STAP cells
Discussion
Methods
References
Acknowledgements
Author information
Extended data figures and tables
Supplementary information
Abstract
Here we report a unique cellular reprogramming phenomenon, called stimulus-triggered acquisition of pluripotency (STAP), which requires neither nuclear transfer nor the introduction of transcription factors.
In STAP, strong external stimuli such as a transient low-pH stressor reprogrammed mammalian somatic cells, resulting in the generation of pluripotent cells.
Through real-time imaging of STAP cells derived from purified lymphocytes, as well as gene rearrangement アナリシーズ, we found that committed somatic cells give rise to STAP cells by reprogramming rather than selection.
Thus, our findings indicate that epigenetic fate determination of mammalian cells can be markedly converted in a context-dependent manner by strong environmental cues.
うーーん。そうなの？
＜a substantial decrease in DNA methylation in the regulatory
regions of pluripotency marker genes.＞
のところdecreaseで外れるという感じの現象なの？何で見るの？
何で見るからそんな曖昧な表現になるの？
