（＊）ビタミンEのサプリメントで前立腺がんリスクが増加、米研究（AFPBB News 2011年10月12日）
ttp://www.afpbb.com/article/life-culture/health/2834436/7913310
ビタミンEのサプリメントの摂取と前立腺がんリスクの17％の上昇の間に強い相関性が見られたとする研究結果が、11日の米国医師会雑誌（Journal of the American Medical Association、JAMA）に発表された。
セレンやビタミンEの摂取による前立腺がんの予防効果を調べる「Selenium and Vitamin E Cancer Prevention Trial（SELECT）」は2001年から、米国立がん研究所（US National Cancer Institute）などの資金提供により、米国、カナダ、プエルトリコの男性3万5000人以上を対象にランダム化比較試験を行った。これは、ブラジルナッツやマグロ、牛肉に含まれる微量ミネラルのセレンおよびビタミンEには前立腺がんリスクを下げる効果がありそうだとの研究結果を受けたもの。
男性を「セレンを摂取する」「ビタミンEを毎日400 IU（国際単位）摂取する」「両方摂取する」「プラシーボ（偽薬）を摂取する」の4グループに分けて追跡調査した。
2008年に発表された中間報告によると、前立腺がんの発症はビタミンEを摂取したグループでやや多かったが、統計的に有意な差ではなかった。ただしその後、ビタミンEによる前立腺がんリスクが統計的に有意な域に近づいていったため、SELECTは2008年に中止された。
今年7月にまとめられた10年間の追跡調査の結果、前立腺がんを発症したのはビタミンEのグループで620人と、突出して多かった。この間の発症者はセレンだけを摂取したグループで575人、セレンとビタミンEの両方を摂取したグループで555人、プラシーボを摂取したグループで529人だった。
研究は、ビタミンEが前立腺がんリスクを押し上げる生物学的な理由は不明だとしながらも、ビタミンEサプリメントのこうした効果は摂取をやめたあとも継続する可能性があると注意を促している。
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