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Then, to check whether hyper-homocysteinemia excessively induces variations of osteo-collagens into AGEs or not, we made tests on rabbits from which ovaries are eliminated ( but they had same remodeled bones as human bones ).
So that, it has been found out that if hyper-homocysteinemia is caused, pentosidines are excessively generated in osteo-collagen and changes of osteo-collagens into AGEs are promoted.
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