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AGEs as aging cross-links are over-inducted into osteo-collagens due to primary osteoporosis, diabetes, renal failure and aging, etc, consequently the strength of bone lowers.
Oxidative stress and saccharification related to ground substantial protein give considerable influences on over-aging of collagen.
By the way, it's impossible to estimate the risk of fracture of bone only on calcium-based parameters dependent on the promotion of bone-absorption and the drop in osteo-density following it.
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