＜内容、目次＞
Overview サーチュイン研究が開いたエイジング・サイエンスの地平
A New Horizon of Aging Science Brought by Sirtuin Biology
【今井眞一郎】
「サーチュイン」が与えた衝撃 ─パンドラの箱はもはや開け放たれた
老化・寿命研究の新たな潮流 ─寿命の制御には限られた数の進化的に保存された遺伝子がかかわっている
サーチュインのNAD 依存性脱アセチル化酵素活性の発見 ─全く前例のない非常にユニークな酵素だったサーチュイン
老化・寿命制御におけるサーチュインの重要性 ─長寿遺伝子（longevity gene）としてのサーチュイン
サーチュインを標的とした創薬の可能性 ─抗老化療法が可能になる日がやってくる
おわりに ─自らの生をより深く見つめるために
Live1 サーチュイン研究〜これまでの10年，これからの10年〜
The Past and The Next Ten Years of Sirtuin Research
【Interview with Leonard P. Guarente ＆ Shin-ichiro Imai】
(1) 老化研究を切り開いたサーチュイン研究の10年の軌跡
The development of sirtuin research in the past decade
(2) 脳でわかったサーチュインの新しい機能〜サーチュイン生物学，次のマイルストーンへ向けて〜
The novel functions of sirtuins in the brain and the next milestone in sirtuin biology
(3) サイエンスの新しいパラダイムを拓くために
Opening new paradigms of science
Live2 サーチュイン研究の創薬に向けた挑戦
The Quest for Drugs Targeting Sirtuins
【Interview with David A. Sinclair】
(1) レスベラトロールの機能の発見とSirtris社設立
The discovery of STACs and the foundation of Sirtris Pharmaceuticals
(2) サーチュインは寿命，健康寿命を延長しうるのか？
Can sirtuins extend human’s lifespan and healthspan?
Live3 ミトコンドリアで機能するサーチュインが拓く新しいバイオロジー
Novel Aspects of Mitochondrial Sirtuins
【Interview with Marcia C. Haigis】
(1) ミトコンドリアで機能するサーチュイン，PIとしてのミッション
Sirtuins in mitochondria, the mission as a PI
(2) ミトコンドリアサーチュインファミリーの創薬への可能性と研究者・女性研究者へのメッセージ
The therapeutic potential of mitochondrial sirtuins, a message for female scientists
Live4 サーチュイン創薬の最前線-バイオベンチャー成功の鍵-
At the Cutting-Edge Front of Sirtuin-Targeting Drug Development-the Key to Success as a Biotech Venture Company-
【Interview with George P. Vlasuk】
(1) サーチュイン創薬への挑戦〜SIRT1活性化メカニズムをめぐる論争〜
The challenges for developing Sirtuin drugs and a controversy over the mechanism of SIRT1 activator
(2) 一流の科学者が“Knowledge Base”としてSirtris社を支える
Scientific Advisory Board at Sirtris as a Knowledge Base
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