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Notably, when cultured in LIF+FBS-containing medium for 4 days, Fgf4-induced stem cells underwent substantial changes in morphology and started to form ES-cell-like compact colonies with strong GFP signals (Fig. 3a). These cells showed expression of pluripotency makers, but not trophoblast markers (Fig. 3b and Extended Data Fig. 6a), and formed teratomas in mice (Extended Data Fig. 6b). These ES-like cells were generated from Fgf4-induced stem cells sorted for strong expression of the trophoblast marker Itga7, but rarely from Itga7-dim cells (Fig. 3c, d).
"Gene Expression Profiling Reveals a Novel Regulatory Role for Sox21 Protein in Mouse Trophoblast Stem Cell Differentiation"
"Gene Expression Profiling Reveals a Novel Regulatory Role for Sox21 in Mouse Trophoblast Stem Cell Differentiation"
"A Resource for the Transcriptional Signature of Bona Fide Trophoblast Stem Cells and Analysis of Their Embryonic Persistence"
2019/3/21(木) 午後 0:20[ Ts.Marker ]返信する
(小保方論文 Published online 29-Jan-14)
Stimulus-triggered fate conversion of somatic cells into pluripotency
Bidirectional developmental potential in reprogrammed cells with acquired pluripotency
(遠藤論文 published online: 21 SEP 2014)
Quality control method for RNA-seq using single nucleotide polymorphism allele frequency
(Moretto Zita M 論文 Epub 2015 Oct 21.)
Gene Expression Profiling Reveals a Novel Regulatory Role for Sox21 Protein in Mouse Trophoblast Stem Cell Differentiation.
(Georg Kuales 論文 Published online 2015 Dec 14. )
A Resource for the Transcriptional Signature of Bona Fide Trophoblast Stem Cells and Analysis of Their Embryonic Persistence
